Our latest publications – Bristol Heart Institute

Catsis, S., Champneys, A. R., Hoyle, R., Currie, C., Enright, J., Cheema, K., Woodall, M., Angelini, G., Nadarajah, R., Gale, C., Gibbison, B. 19 July 2023 Process modelling of NHS cardiovascular waiting lists in response to the COVID-19 pandemic. BMJ Journals
Tim Dong · Shubhra Sinha Shubhra Sinha · Ben Zhai, Gianni D Angelini July 2023 Cardiac surgery risk prediction using ensemble machine learning to incorporate legacy risk scores: A benchmarking study Sage Journals
Ashar Asif, Andrew I. U. Shearn, Mark S. Turner, Giovanni Biglino January 2023 Assessment of post-infarct ventricular septal defects through 3D printing and statistical shape analysis Journal of 3D Printing in Medicine
Xiaojuan Zhao, Dominic Alibhai, Tony G. Walsh, Nathalie Tarassova, Maximilian Englert, Semra Z. Birol, Yong Li, Christopher M. Williams, Chris R. Neal, Philipp Burkard, Stephen J. Cross, Elizabeth W. Aitken, Amie K. Waller, José Ballester Beltrán, Peter W. Gunning, Edna C. Hardeman, Ejaife O. Agbani, Bernhard Nieswandt, Ingeborg Hers, Cedric Ghevaert & Alastair W. Poole. 7 July 2023 Highly efficient platelet generation in lung vasculature reproduced by microfluidics Nature Communications
Jeremy Chan, Arnaldo Dimagli, Tim Dong, Daniel P Fudulu, Shubhra Sinha, Gianni D Angelini 31 July 2023 Trend and early clinical outcomes of Off Pump Coronary Artery Bypass Grafting in the United Kingdom European Journal of Cardio-Thoracic Surgery, ezad272
Katrina Hope¹, Ben Chant¹, Thomas Hinton¹, Adrian H Kendrick^1 2, Angus K Nightingale^1 3, Julian F R Paton⁴, Emma C Hart¹Ventilatory Efficiency Is Reduced in People With Hypertension During Exercise 4 July 23 https://pubmed.ncbi.nlm.nih.gov/37345800/
Murine studies and expressional analyses of human cardiac pericytes reveal novel trajectories of SARS-CoV-2 Spike protein-induced microvascular damage – Signal Transduction and Targeted Therapy 2 June 2023 https://www.nature.com/articles/s41392-023-01489-2
Shubhra Sinha, MBBS, Tim Dong, MSc, Arnaldo Dimagli, MD, Hunaid A Vohra, PhD, Chris Holmes, PhD, Umberto Benedetto, PhD, Gianni D Angelini, MD Author Notes. Comparison of Machine Learning Techniques in Prediction of Mortality following Cardiac Surgery: Analysis of over 220,000 patients from a Large National Database. European Journal of Cardio-Thoracic Surgery
Pradeep Narayan FRCS(CTh) ¹ ∗, Arnaldo Dimagli MD ² ∗, Daniel P. Fudulu PhD ², Shubhra Sinha MD ², Tim Dong MSc ², Jeremy Chan MD ², Gianni D. Angelini MD ²Risk Factors and Outcomes of Reoperative Surgical Aortic Valve Replacement in the United Kingdom. The Annals of Thoracic Surgery.
Monica Cattaneo ¹, Antonio P Beltrami ², Anita C Thomas ³, Gaia Spinetti ¹, Valeria Alvino ³, Elisa Avolio ³, Claudia Veneziano ², Irene Giulia Rolle ², Sandro Sponga ², Elena Sangalli ¹, Anna Maciag ¹, Fabrizio Dal Piaz ⁴, Carmine Vecchione ^4,5, Aishah Alenezi ⁶, Stephen Paisey ⁶, Annibale A Puca ¹ ⁴, Paolo Madeddu ³ The longevity-associated BPIFB4 gene supports cardiac function and vascularization in aging cardiomyopathy. Cardiovasc Res. 2023 Jan 13;cvad008. PMID: 36635236 DOI: 10.1093/cvr/cvad008. Online ahead of print.
Jeremy Chan¹, Arnaldo Dimagli¹, Daniel P. Fudulu¹, Shubhra Sinha¹, Pradeep Narayan¹,², Tim Dong¹ and Gianni D. Angelini¹. ¹Bristol Heart Institute, University of Bristol, Bristol, United Kingdom ²NH Rabindranath Tagore International Institute of Cardiac Sciences, Kolkata, India. Trend and early outcomes in isolated surgical aortic valve replacement in the United Kingdom. 9 January 2023 Frontiers in Cardiovascular Medicine
Daniel J. P. Burns MD, MPhil, Gianni D. Angelini MD, Umberto Benedetto MD, PhD, Massimo Caputo MD, Franco Ciulli MD, Hunaid A. Vohra MD. Early mortality and neurologic outcomes following mitral valve surgery in the very elderly. 6 November 2022. https://onlinelibrary.wiley.com/
Antonio M. Calafiore MD, Ruggero de Paulis MD, Severino Iesu MD, Domenico Paparella MD, Gianni Angelini MD, Mattia Scognamiglio MD, Paolo Centofanti MD, Salvatore Nicolardi MD, Pierpaolo Chivasso MD, Carlo Canosa MD, Salvatore Zaccaria MD, Luigi de Martino MD, Diego Magnano MD, Giuseppe Mastrototaro MD, Michele Di Mauro MD. Brain and lower body protection during aortic arch surgery. 20 November 2022 https://onlinelibrary.wiley.com/
Marco Moscarelli MD, PhD, Domenico Paparella MD, Gianni D. Angelini MD, PhD, Francesco Giannini MD, PhD, Gaetano Contegiacomo MD, Alfredo Marchese MD. The influence of metabolic syndrome in heart valve intervention. A multi-centric study. 22 November 2022. https://onlinelibrary.wiley.com/
Jeremy Chan MRes, MRCS,Arnaldo Dimagli MD,Daniel P. Fudulu MD, PhD,Tim Dong,Ester Mikova,Gianni D. Angelini MD, MCh, FRCS, FMedSci. On- versus off-pump CABG in octogenarians: A propensity-matched analysis from the UK National Database. 02 November 2022 https://onlinelibrary.wiley.com/
Chan, J., Dimagli, A., Fudulu, D. P., Dong, T., Sinha, S. & Angelini, G. D. (2022) Trend and factors associated with multiple arterial revascularization in coronary artery bypass grafting in the UK, 11 July 2022 In: European Journal of Cardio-Thoracic Surgery.
Lauren Kari Dixon MBChB, MRes, MRCS,Arnaldo Dimagli MD,Ettorino Di Tommaso MD,Shubhra Sinha MBBS, BSc(Hons),Daniel P. Fudulu MD, MRCSEd, PhD,Manraj Sandhu MBBS, MRes, MRCS,Umberto Benedetto MD, PhD,Gianni D. Angelini MD, MCh, FRCS, FECTS, F, Med, Sci … See fewer authors (2022) Females have an increased risk of short-term mortality after cardiac surgery compared to males: Insights from a national database, First published:18 September 2022 Journal of Cardiac Surgery Volume 37, Issue 11 https://onlinelibrary.wiley.com/
Avolio E et al. (2022) Cardiac pericyte reprogramming by MEK inhibition promotes arteriologenesis and angiogenesis of the ischemic heart. Journal of Clinical Investigation, vol 132, no 10 10.1172/JCI152308 e152308
Skeffington, K. L, Mohamed Ahmed E., Rapetto F., Chanoit G., Bond A.R., Vardeu A., Ghorbel M.T., Suleiman M.S., Caputo M. (2023 June) The effect of cardioplegic supplementation with sildenafil on cardiac energetics in a piglet model of cardiopulmonary bypass and cardioplegic arrest with warm or cold cardioplegia. Front Cardiovasc Med. 7;10:1194645. doi: 10.3389/fcvm.2023.1194645. eCollection 2023
Akowuah E.F., Maier R.H., Hancock H.C., Kharatikoopaei E., Vale L., Fernandez-Garcia C., Ogundimu E., Wagnild J., Mathias A., Walmsley Z., Howe N., Kasim A., Graham R., Murphy G.J., Zacharias J. (2023); UK Mini Mitral Trial Investigators. Minithoracotomy vs Conventional Sternotomy for Mitral Valve Repair: A Randomized Clinical Trial. JAMA. Jun 13;329(22):1957-1966. doi: 10.1001/jama.2023.7800.
Heys R., Walker-Smith T., Evans R., Caputo M., Culliford L., Reeves B., Rogers C., Turner M., Hamilton M., Sheehan K., Viola N., Stoica S., Wright K., Angelini G., Parry A. (2023 Jun) Off-pump injectable versus on-pump conventional tissue valves for pulmonary valve replacement: the injectable valve implantation randomised trial (INVITE). BMJ Open. 1;13(6):e065192. doi: 10.1136/bmjopen-2022-065192.
Al-Zubaidi F., Pufulete M., Sinha S., Kendall S., Moorjani N., Caputo M., Angelini G.D., Vohra H.A. (2023 May) Mitral Repair versus Replacement: Twenty-Year Outcome Trends in the UK (2000-2019). Perfusion. 5:2676591231174579. doi: 10.1177/02676591231174579.
Hussain S., Swystun A.G., Caputo M., Angelini G.D., Vohra H.A. (2023 May) A review and meta-analysis of conventional sternotomy versus minimally invasive mitral valve surgery for degenerative mitral valve disease focused on the last decade of evidence. Perfusion. 5:2676591231174579. doi: 10.1177/02676591231174579.
Hasan B.S., Bhatti A., Mohsin S., Barach P., Ahmed E., Ali S., Amanullah M., Ansong A., Banu T., Beaton A., Bolman R.M. 3rd, Borim B.C., Breinholt J.P., Callus E., Caputo M., Cardarelli M., Hernandez T.C., Croti U.A., Ejigu Y.M., Fenton K., Gomanju A., Harahsheh A.S., Hesslein P., Hugo-Hamman C., Khan S., Kpodonu J., Kumar R.K., Jenkins K.J., Lakhoo K., Malik M., Nichani S., Novick W.M., Overman D., Quenot A.P., Patton Bolman C., Pearson D., Raju V., Ross S., Sandoval N.F., Sholler G., Sharma R., Shidhika F., Sivalingam S., Verstappen A., Vervoort D., Zühlke L.J., Zheleva B. (2023 May) Recommendations for developing effective and safe paediatric and congenital heart disease services in low- income and middle- income countries: a public health framework. BMJ Glob Health. 8(5):e012049. doi: 10.1136/bmjgh-2023-012049
Hockham C., Linschoten M., Asselbergs F.W., Ghossein C., Woodward M., Peters S.A.E. (2023 Feb 14) CAPACITY-COVID Collaborative Consortium. Sex differences in cardiovascular complications and mortality in hospital patients with covid-19: registry based observational study. BMJ Med. 2(1):e000245. doi: 10.1136/bmjmed-2022-000245. eCollection 2023.
Vohra H.A., Salmasi M.Y., Mohamed F., Shehata M., Bahrami B., Caputo M., Deshpande R., Bapat V., Bahrami T., Birdi I., Zacharias J. (2023 Mar) Consensus statement on aortic valve replacement via an anterior right minithoracotomy in the UK healthcare setting. Open Heart. 10(1):e002194. doi: 10.1136/openhrt-2022-002194.
Asif A., Shearn A.I., Turner M.S., Ordoñez M.V., Sophocleous F., Mendez-Santos A., Valverde I., Angelini G.D., Caputo M., Hamilton M.C., Biglino G. (2023 Mar) Assessment of post-infarct ventricular septal defects through 3D printing and statistical shape analysis. J 3D Print Med. 7(1):3DP3. doi: 10.2217/3dp-2022-0012. Epub 2023 Jan 18.
Stoica S., Smartt H., Heys R., Sheehan K., Walker-Smith T., Parry A., Beringer R., Ttofi I., Evans R., Dabner L., Ghorbel M.T., Lansdowne W., Reeves B.C., Angelini G.D., Rogers C.A., Caputo M. (2023 Feb 17) Warm versus cold-blood cardioplegia in paediatric congenital heart surgery: a randomized trial. Eur J Cardiothorac Surg. ezad041. doi: 10.1093/ejcts/ezad041.
Taylor K., Wootton R.E., Yang Q., Oddie S., Wright J., Yang T.C., Magnus M., Andreassen O.A., Borges M.C., Caputo M., Lawlor D.A. (2023 Feb) The effect of maternal BMI, smoking and alcohol on congenital heart diseases: a Mendelian randomisation study. BMC Med. 1;21(1):35. doi: 10.1186/s12916-023-02731-y.
Harris A.G., Salih T., Ghorbel M.T., Caputo M., Biglino G., Carrabba M. (2023 Jan 2) Biological Scaffolds for Congenital Heart Disease. Bioengineering (Basel). 10(1):57. doi: 10.3390/bioengineering10010057.
Mires S., Reddy S., Skerritt C., Caputo M., Eastwood K.A. (2023 Jan 8) Maternal metabolomic profiling and congenital heart disease risk in offspring: A systematic review of observational studies. Prenat Diagn. doi: 10.1002/pd.6301.
Avolio E., Prashant K. Srivastava, Jiahui J., Carrabba M., Tsang C.T.W., Yue G., Thomas A.C., Gupta K., Berger I., Emanueli C. Madeddu P. (2 June 2023) Murine studies and expressional analyses of human cardiac pericytes reveal novel trajectories of SARS-CoV-2 Spike protein-induced microvascular damage – Signal Transduction and Targeted Therapy
Shubhra Sinha, MBBS, Tim Dong, MSc, Arnaldo Dimagli, MD, Hunaid A Vohra, PhD, Chris Holmes, PhD, Umberto Benedetto, PhD, Gianni D Angelini, MD (June 2023) Comparison of Machine Learning Techniques in Prediction of Mortality following Cardiac Surgery: Analysis of over 220,000 patients from a Large National Database. European Journal of Cardio-Thoracic Surgery
Pradeep Narayan FRCS(CTh) ¹ ∗, Arnaldo Dimagli MD ² ∗, Daniel P. Fudulu PhD ², Shubhra Sinha MD ², Tim Dong MSc ², Jeremy Chan MD ², Gianni D. Angelini MD 2 (April 2017) Risk Factors and Outcomes of Reoperative Surgical Aortic Valve Replacement in the United Kingdom. The Annals of Thoracic Surgery. https://doi.org/10.1016/j.athoracsur.2022.12.045
Monica Cattaneo ¹, Antonio P Beltrami ², Anita C Thomas ³, Gaia Spinetti ¹, Valeria Alvino ³, Elisa Avolio ³, Claudia Veneziano ², Irene Giulia Rolle ², Sandro Sponga ², Elena Sangalli ¹, Anna Maciag ¹, Fabrizio Dal Piaz ⁴, Carmine Vecchione ^4,5, Aishah Alenezi ⁶, Stephen Paisey ⁶, Annibale A Puca ¹ ⁴, Paolo Madeddu ³ (2023) The longevity-associated BPIFB4 gene supports cardiac function and vascularization in aging cardiomyopathy. Cardiovasc Res. 2023 Jan 13;cvad008. PMID: 36635236 DOI: 10.1093/cvr/cvad008. Online ahead of print.
Jeremy Chan¹, Arnaldo Dimagli¹, Daniel P. Fudulu¹, Shubhra Sinha¹, Pradeep Narayan¹,², Tim Dong¹ and Gianni D. Angelini¹. ¹Bristol Heart Institute, University of Bristol, Bristol, United Kingdom ²NH Rabindranath Tagore International Institute of Cardiac Sciences, Kolkata, India. (9 January 2023) Trend and early outcomes in isolated surgical aortic valve replacement in the United Kingdom. Frontiers in Cardiovascular Medicine
Daniel J. P. Burns M.D., MPhil, Gianni D. Angelini M.D., Umberto Benedetto M.D., PhD, Massimo Caputo M.D., Franco Ciulli M.D., Hunaid A. Vohra M.D. (6 November 2022) Early mortality and neurologic outcomes following mitral valve surgery in the very elderly. https://onlinelibrary.wiley.com/
Antonio M. Calafiore MD, Ruggero de Paulis MD, Severino Iesu MD, Domenico Paparella MD, Gianni Angelini MD, Mattia Scognamiglio MD, Paolo Centofanti MD, Salvatore Nicolardi MD, Pierpaolo Chivasso MD, Carlo Canosa MD, Salvatore Zaccaria MD, Luigi de Martino MD, Diego Magnano MD, Giuseppe Mastrototaro MD, Michele Di Mauro MD. (20 November 2022) Brain and lower body protection during aortic arch surgery. https://onlinelibrary.wiley.com/
Marco Moscarelli MD, PhD, Domenico Paparella MD, Gianni D. Angelini MD, PhD, Francesco Giannini MD, PhD, Gaetano Contegiacomo MD, Alfredo Marchese MD. (22 November 2022) The influence of metabolic syndrome in heart valve intervention. A multi-centric study. https://onlinelibrary.wiley.com/
Jeremy Chan MRes, MRCS,Arnaldo Dimagli MD,Daniel P. Fudulu MD, PhD,Tim Dong,Ester Mikova,Gianni D. Angelini MD, MCh, FRCS, FMedSci. (02 November 2022) On- versus off-pump CABG in octogenarians: A propensity-matched analysis from the UK National Database. https://onlinelibrary.wiley.com/
Chan, J., Dimagli, A., Fudulu, D. P., Dong, T., Sinha, S. & Angelini, G. D. (11 July 2022) Trend and factors associated with multiple arterial revascularization in coronary artery bypass grafting in the UK, In: European Journal of Cardio-Thoracic Surgery.
Lauren Kari Dixon MBChB, MRes, MRCS,Arnaldo Dimagli MD,Ettorino Di Tommaso MD,Shubhra Sinha MBBS, BSc(Hons),Daniel P. Fudulu MD, MRCSEd, PhD,Manraj Sandhu MBBS, MRes, MRCS,Umberto Benedetto MD, PhD,Gianni D. Angelini MD, MCh, FRCS, FECTS, F, Med, Sci (2022) Females have an increased risk of short-term mortality after cardiac surgery compared to males: Insights from a national database, First published:18 September 2022 Journal of Cardiac Surgery Volume 37, Issue 11 https://onlinelibrary.wiley.com/
Avolio E et al. (2022) Cardiac pericyte reprogramming by MEK inhibition promotes arteriologenesis and angiogenesis of the ischemic heart. Journal of Clinical Investigation, vol 132, no 10 10.1172/JCI152308 e152308
Abdul-Ghani S et al. (2022) Effect of cardioplegic arrest and reperfusion on left and right ventricular proteome/phosphoproteome in patients undergoing surgery for coronary or aortic valve disease International Journal of Molecular Medicine, vol 49, no 6 10.3892/ijmm.2022.5133 77
Avolio E et al. (2022) Intravascular administration of soluble SARS-CoV-2 Spike protein triggers non-infective heart and lung inflammation and vascular pericytes rarefaction in healthy mice : ESC Congress 2022 European Heart Journal Supplements

To see all our latest publications, follow this link